哪些营养素能帮助你的关节?
2023/08/05 08:58:09
鎱㈡у叧鑺傜柤鐥涘彂鐢熺巼姝ｅ湪涓婂崌,棰勮鍒2040骞,7840涓(25.9%)18宀佷互涓婄編鍥芥垚浜哄皢琚瘖鏂负鍏宠妭鐐庛1 鏈甯歌鐨勭棁鐘舵槸鑶濆叧鑺傘佹墜鑵曘佹墜鎸囥佽偐鑶鍜岄珛鍏宠妭涓嶉傘
璁稿鍖荤敓鎺ㄨ崘鐨勯閫夌紦瑙ｆ柟娉曟槸闈炵被鍥洪唶娑堢値鑽(NSAIDs)銆傝櫧鐒惰繖浜涜嵂鐗╁彲鑳芥湁鍔╀簬鏆傛椂闃绘柇鐤肩棝骞跺噺灏戠値鐥,浣嗛潪澶勬柟(OTC)姝㈢棝鑽疄闄呬笂骞舵病鏈夊府鍔╁姞鍥哄拰婊嬪吇鏋勬垚鍏宠妭鐨勫叧閿粨鏋勩
骞歌繍鐨勬槸,宸茬粡鍙戠幇璁稿鑶抽琛ュ厖鍓傛棦鑳芥敮鎸佸叧鑺傚仴搴,鍙堝叿鏈夊叾浠栫泭澶勩傝櫧鐒舵ユу垱浼や細瀵艰嚧閮ㄥ垎鍏宠妭鍔熻兘闅滅,浣嗗ぇ澶氭暟鍏宠妭閫鍖栭兘鏄紦鎱㈠彂鐢熺殑銆備繚鎸佸叧鑺傚仴搴峰拰鎬ц兘鐨勫叧閿槸姝ｇ‘鐨勮繍鍔ㄥ舰寮忋佷紭璐ㄧ殑鏃ュ父钀ュ吇鍜岄拡瀵规х殑琛ュ厖鍓傘傗
鏈浣冲叧鑺傝惀鍏荤礌:
1.鐢茬～姘ㄩ吀鐩(MSM)
鐢茬～姘ㄩ吀鐩(MSM)鏄竴绉嶅惈纭垎瀛,宸茬煡鍙互閫氳繃浠ヤ笅涓ょ鏂瑰紡鏀寔鍏宠妭鍋ュ悍:淇冭繘杞鐢熸垚鍜屽叿鏈夋姉鐐庝綔鐢ㄣ2 鈥
浜嬪疄涓,鐮旂┒浜哄憳鎸囧嚭:鈥...MSM琛嶇敓纭浜轰綋鍚告敹杩涘叆杞缁勭粐,杩欒〃鏄嶮SM鍙敤浜庨闃叉垨娌荤枟鐐庣棁鐩稿叧鐨勫叧鑺傜柧鐥呫傗 2 鈥
鏈杩戝湪12鍛ㄥ唴瀵规劅瑙夎啙鍏宠妭鐤肩棝鈥滆交寰濈殑鍋ュ悍鍙備笌鑰呯殑鐮旂┒鍙戠幇,姣忔棩琛ュ厖2000姣厠MSM鍙互鏀瑰杽鑶濆叧鑺傜姸鍐靛拰鍏ㄨ韩鍋ュ悍鐘跺喌,鐩告瘮瀹夋叞鍓傜粍鏈夋樉鐫宸紓銆2 鈥
杩欎竴鍙戠幇鍊煎緱鍏虫敞,鍥犱负杩欐槸棣栨閽堝鈥滃仴搴封濅釜浣撹繘琛岀殑涓村簥璇曢獙,鑰屼箣鍓嶇殑MSM鐮旂┒閮芥槸閽堝鎮ｆ湁楠ㄥ叧鑺傜値鐨勪釜浣撹繘琛岀殑銆3,4 鈥
2.钁¤悇绯栬兒
钁¤悇绯栬兒鏄敤浜庡叧鑺傚仴搴风殑涓ょ鏈甯歌鍜屼娇鐢ㄦ椂闂存渶闀跨殑鑶抽琛ュ厖鍓備箣涓(鍙︿竴绉嶆槸杞绱)銆傚畠鏄蒋楠ㄧ殑缁勬垚閮ㄥ垎,涔嬪墠鐨勭爺绌惰〃鏄庡畠鍙兘鏈夊姪浜庢敼鍠勫叧鑺傝垝閫傚害骞舵敮鎸佸仴搴风殑鍏宠妭銆5,6
闄や簡鏀寔鍏宠妭鐨勭壒鎬у,钁¤悇绯栬兒杩樹笌鍏朵粬鐩婂鐩稿叧,鐗瑰埆鏄湪蹇冭绠′唬璋㈠仴搴峰拰鍏ㄥ洜姝讳骸鐜囨柟闈7,8,9渚嬪,鍔ㄧ墿鐮旂┒琛ㄦ槑,钁¤悇绯栬兒鐨勭粰浜堝彲鑳芥ā褰蜂綆纰虫按鍖栧悎鐗╅ギ椋熺殑鏁堟灉,浠庤屽鍔犲鍛姐10鏈杩戠殑涓椤瑰叡鍖呮嫭杩48涓囧悕鍙備笌鑰呯殑涓栦唬鐮旂┒鍙戠幇,瀹氭湡琛ュ厖钁¤悇绯栬兒涓庡績鍔涜“绔闄╅檷浣庣浉鍏,涓庨仐浼犻闄╃姸鎬佹棤鍏炽11 鈥
鏂扮殑鐮旂┒涔熸寚鍑轰簡涓浜涜剳鍋ュ悍鐩婂銆備箣鍓嶇殑鐮旂┒琛ㄦ槑钁¤悇绯栬兒鍙互绌胯繃琛鑴戝睆闅(BBB),鍦ㄩ偅瑁″畠鍙兘鍏锋湁绁炵粡淇濇姢鍜屾姉鐐庝綔鐢ㄣ12,13 鈥
涓椤瑰湪鑻卞浗鐢熺墿鏍锋湰搴撳紑灞曠殑澶у瀷鐮旂┒,鍖呮嫭杩50涓囪嫳鍥戒汉鐨勬暟鎹,鍙戣〃鍦ㄩ珮搴﹀皧鏁殑BMC鍖诲鏉傚織涓,鐮旂┒浜嗗畾鏈熶娇鐢ㄨ憽钀勭硸鑳轰笌鍏ㄥ洜鎬уけ鏅虹棁銆侀樋灏旇尐娴烽粯姘忕棁鍜岃绠℃уけ鏅虹棁椋庨櫓鐨勫叧鑱斻14鍦ㄥぇ绾9骞寸殑闅忚鏈熷唴,鐮旂┒浜哄憳璁板綍浜2458渚嬪叏鍥犳уけ鏅虹棁,924渚嬮樋灏旇尐娴烽粯姘忕棁鍜491渚嬭绠℃уけ鏅虹棁銆傗
鍦ㄨ鐮旂┒缁撴潫鏃,鍥㈤槦鍙戠幇瀹氭湡琛ュ厖钁¤悇绯栬兒涓庡叏鍥犳уけ鏅虹棁椋庨櫓闄嶄綆15%銆侀樋灏旇尐娴烽粯姘忕棁椋庨櫓闄嶄綆17%鍜岃绠℃уけ鏅虹棁椋庨櫓闄嶄綆26%鐩稿叧銆14瀹氭湡鏈嶇敤钁¤悇绯栬兒鐨勪汉缇や腑,鐐庣棁鐢熺墿鏍囧織鐗〤鍙嶅簲铔嬬櫧(CRP)姘村钩鏄剧潃闄嶄綆銆15 鈥
3.杞绱
杞绱犵粡甯镐笌钁¤悇绯栬兒涓璧疯ˉ鍏,鑰屼袱鑰呯殑缁勫悎涓庡崟鐙娇鐢ㄧ浉姣,鍦ㄥ叧鑺傛敮鎸佹晥鏋滄柟闈㈢殑缁撴灉鏇翠负鏈夊埄銆16
杞绱犳槸涓绉嶈嚜鐒剁敓鎴愮殑鐗╄川,鍙府鍔╄韩浣撶淮鎸佸叧鑺備腑鐨勬祦鍔ㄦу拰寮规с傛垜浠箣鍓嶅己璋冪殑鐮旂┒琛ㄦ槑,琛ュ厖杞绱犲彲鑳戒細鏀瑰杽鍏宠妭鑸掗傚害鍜屾暣浣撶敓娲昏川閲忋16
涓庤憽钀勭硸鑳轰竴鏍,杞绱犱篃琚彂鐜板彲鎻愪緵鍏宠妭鍋ュ悍涔嬪鐨勭泭澶勩傚姩鑴夌‖鍖栨槸涓绉嶆參鎬х値鐥囨х柧鐥,绫讳技鍏宠妭鐐庢槸鐐庣棁鎬х柧鐥呫傜爺绌惰〃鏄,杞绱犲彲鑳戒細鎶戝埗NFkB淇″彿浼犲閫氳矾涓嬫父鐨勬煇浜涚値鐥囧洜瀛,鍖呮嫭IL-1尾銆両L-6銆乀NF-伪鍜孭GE2,浠ュ強COX-2鐨勮〃杈俱17,18
2021骞翠竴椤瑰ぇ瑙勬ā涓栦唬鐮旂┒,鍖呮嫭瓒呰繃370涓囦汉,鍙戠幇浣跨敤杞绱犱笌蹇冭剰鐥呭彂浣滈闄╅檷浣庣害40%鐩稿叧銆19杩欎簺鍙戠幇寰楀埌浜哅orrison绛変汉鍦20涓栫邯70骞翠唬棣栨鍙戠幇杞绱犳綔鍦ㄥ績琛绠＄泭澶勭殑鐮旂┒鐨勬敮鎸併20 鈥
棰濆鐨勫姩鐗╃爺绌惰繕鍙戠幇,杞绱犲彲鑳借兘澶熷噺灏戣绠″唴鏂戝潡鐨勫ぇ灏忓苟淇鍙楁崯鐨勮绠″銆21 鈥
涔抽灞炴鐗〣oswellia serrata鏄竴绉嶅叿鏈変赴瀵屼紶缁熺枟娉曞簲鐢ㄥ巻鍙茬殑妞嶇墿,灏ゅ叾瀵规參鎬х値鐥囨潯浠堕潪甯告湁鏁堛傜爺绌朵汉鍛樺凡缁忚瘑鍒簡涔抽涓瓨鍦ㄧ殑涓绉嶅叧閿敓鐗╂椿鎬ф垚鍒嗕箼閰板熀-11-閰-尾-榫熸澘棣欑儻閰(AKBA),鍙戠幇瀹冭兘鎶戝埗鐐庣棁鍜屾牳鍥犲瓙-魏B(NF-魏B)淇″彿閫氳矾銆22,23,24 AKBA涔熻璇佹槑鏄...5-鑴傛哀鍚堥叾(5-LOX)鐨勬渶寮烘姂鍒跺墏,杩欐槸涓绉嶈礋璐ｇ値鐥囩殑閰垛濄25 鈥
鏈鏂扮殑鐮旂┒琛ㄦ槑AKBA鍙兘瀵逛腑鏋㈢缁忕郴缁熴佸懆鍥寸缁忕郴缁熶互鍙婂厤鐤敮鎸佹湁鐩婂銆26,27,28 鈥
Wang绛変汉鏈杩戠殑涓瀵圭爺绌惰杞戒簡AKBA缁欎簣鍚庡娌荤枟鍧愰绁炵粡鎹熶激鏈夌缁忓啀鐢熺泭澶勩26,27 鈥 鍏蜂綋鏉ヨ,鐮旂┒浜哄憳娉ㄦ剰鍒:
鈥滃湪鍒嗗瓙姘村钩涓,AKBA鍙互閫氳繃鎶戝埗楂撹繃姘у寲鐗╅叾鐨勮〃杈惧拰鍑忓皯鐐庣棁鍙嶅簲鏉ュ鍔犵缁忚惀鍏诲洜瀛愮殑琛ㄨ揪,杩欏彲鑳戒績杩涘彈鎹熷潗楠ㄧ缁忕殑楂撻灅鍐嶇敓鍜岃酱绐佸啀鐢熴傗26
AKBA缁欒嵂褰卞搷鐨勭缁忚惀鍏诲洜瀛愬寘鎷剳婧愭х缁忚惀鍏诲洜瀛(BDNF)鍜岀缁忕敓闀垮洜瀛(NGF)- 杩欎袱绉嶇缁忚偨鍒嗗埆璋冭妭绁炵粡鍏冪殑鐢熼暱銆佸彂鑲插拰缁存寔銆26
鐮旂┒浜哄憳杩樻寚鍑,AKBA閮ㄥ垎閫氳繃鈥滃噺灏戠値鐥囧弽搴,淇冭繘楂撻灅鍜岃酱绐佸啀鐢熲濇潵澧炲姞杩欎簺绁炵粡钀ュ吇鍥犲瓙銆26
4.濮滈粍
浣滀负浜氭床鑿滆偞鐨勪富瑕侀厤鏂,濮滈粍鍦ㄤ腑鍖诲拰闃胯偛鍚犻檧鑽墿鐨勬姉鐐庢綔鍔涗篃鏈夋偁涔呯殑搴旂敤鍘嗗彶銆備簨瀹炰笂,2016骞寸殑涓椤硅崯钀冨垎鏋愬拰绯荤粺缁艰堪鍙戠幇,濮滈粍瀵规敼鍠勫叧鑺傜柤鐥涚棁鐘剁殑鏁堟灉涓庣儹闂ㄩ潪澶勬柟闈炵斁浣撴姉鐐庤嵂鐩稿綋銆29 鈥
濮滈粍绱犲強濮滈粍涓叾浠栫敓鐗╂椿鎬ф垚鍒嗗彲璋冭妭NF-魏B淇″彿閫氳矾銆佷績鐐庣棁缁嗚優鍥犲瓙濡傜櫧缁嗚優浠嬬礌鐨勪骇鐢熶互鍙婄７鑴傞叾A2銆丆OX-2鍜5-LOX鐨勬椿鎬с30,31
铏界劧濮滈粍/濮滈粍绱犲湪鍏宠妭鏀寔鍜岃垝缂撴ф柟闈㈢殑鍔熸晥宸插湪鐮旂┒鍜屼紶缁熷簲鐢ㄤ腑寰楀埌鑹ソ寤虹珛,浣嗘柊鐨勭爺绌朵粛鍦ㄦ寔缁繘琛屽拰鍙戣〃銆傛渶杩,涓椤瑰惈鏈夊榛勭殑婧峰悎鐗┾滃噺杞讳簡KOA(鑶濆叧鑺傞鐐)鎮ｈ呯殑鍏宠妭鐤肩棝,鏀瑰杽浜嗚倢鑲夐楠煎姛鑳藉拰鍏宠妭娲诲姩鑳藉姏鈥濄32 鍙楄瘯鑰呭湪30澶╁唴鏈嶇敤瀹夋叞鍓傘250mg濮滈粍/閲戞ū瀛愭彁鍙栫墿鎴1000mg濮滈粍鍜屼钩棣欐彁鍙栫墿鐨勬悍鍚堢墿銆傛湇鐢ㄥ榛/閲戞ū瀛愭悍鍚堢墿鐨勪汉鍛樻敼鍠勪簡韬綋鏈鸿兘,鍑忚交浜嗗叧鑺傜柤鐥涘拰鍍电‖鐨勭棁鐘躲32 鈥
5.鑳跺師铔嬬櫧(浼撮殢缁寸敓绱燙!)
鑳跺師铔嬬櫧鏄綋鍐呮渶涓板瘜鐨勮泲鐧借川,涓轰綘鐨勮韩浣撴彁渚涚粨鏋勫拰鐢熺墿鈥滅矘鍚堝墏鈥,浣胯韩浣撳悇閮ㄥ垎绱у瘑缁撳悎銆傝兌鍘熻泲鐧藉瓨鍦ㄤ簬澶村彂銆佺毊鑲ゅ拰鎸囩敳,涔熷瓨鍦ㄤ簬楠ㄩ銆侀煣甯︺佸叧鑺傘佽蒋楠ㄣ佽倢鑲夊拰琛绠′腑銆
灏界浣撳唴瀛樺湪杩30绉嶄笉鍚岀被鍨嬬殑鑳跺師铔嬬櫧,浣嗘渶涓板瘜鐨勭被鍨嬫槸:
鈥鍨
鈥I鍨
鈥II鍨
韬綋澶╃劧浼氫骇鐢熻兌鍘熻泲鐧(浣嗕笌澶у鏁颁簨鐗╀竴鏍),闅忕潃骞撮緞澧為暱,韬綋鍚堟垚鑳跺師铔嬬櫧鐨勮兘鍔涗細涓嬮檷銆傝ˉ鍏呰兌鍘熻泲鐧芥彁渚涗簡涓涓粡娴庡彲琛岀殑閫夋嫨,閫傚悎閭ｄ簺瀵绘眰澧炲姞鑳跺師铔嬬櫧鑲芥憚鍏ラ噺鐨勪汉缇ゃ
浣跨敤鐗涙簮鑳跺師铔嬬櫧鑲(瀵屽惈I鍨嬪拰III鍨)涓嶶C-II(2鍨嬭兌鍘熻泲鐧)鐨勭粍鍚堝彲鍒烘縺鑳跺師铔嬬櫧鐨勪骇鐢,骞舵彁渚涙敮鎸佽兌鍘熻泲鐧藉悎鎴愭墍闇鐨勫叧閿皑鍩洪吀(鐢樻皑閰搞佽劘姘ㄩ吀鍜岀緹鑴皑閰)銆33,34
闄や簡涔嬪墠鐨勭爺绌惰瘉鏄庤兌鍘熻泲鐧借ˉ鍏呭鍏宠妭鐨勬敮鎸佺泭澶,2018骞寸殑绯荤粺缁艰堪鎬荤粨閬,灏嗙淮鐢熺礌C(涓绉嶆祦琛岀殑鍏嶇柅鏀寔琛ュ厖鍓傚拰鎶楁哀鍖栧墏)涓庤兌鍘熻泲鐧界粍鍚堚滃彲鑳戒細淇冭繘楠ㄦ姌鍚庨楠兼剤鍚,澧炲姞I鍨嬭兌鍘熻泲鐧界殑鍚堟垚,骞跺噺灏戞哀鍖栧簲婵鍙傛暟鈥濄35 鈥
鍙傝冿細
Hootman JM, Helmick CG, Barbour KE, Theis KA, Boring MA.Updated projected prevalence of self-reported doctor-diagnosed arthritis andarthritis-attributable activity limitation among US adults, 2015-2040.Arthritis & Rheumatol. 2016;68(7):1582-1587. doi: 10.1002/art.39692. PubMedPMID: 27015600.
Toguchi A, Noguchi N, Kanno T, Yamada A.Methylsulfonylmethane Improves Knee Quality of Life in Participants with MildKnee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients2023, 15, 2995. https://doi.org/10.3390/nu15132995
Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N,Elbaz A, Beer Y, Debi R. Efficacy of methylsulfonylmethane supplementation onosteoarthritis of the knee: a randomized controlled study. BMC ComplementAltern Med. 2011 Jun 27;11:50. doi: 10.1186/1472-6882-11-50. PMID: 21708034;PMCID: PMC3141601.
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璁稿鍖荤敓鎺ㄨ崘鐨勯閫夌紦瑙ｆ柟娉曟槸闈炵被鍥洪唶娑堢値鑽(NSAIDs)銆傝櫧鐒惰繖浜涜嵂鐗╁彲鑳芥湁鍔╀簬鏆傛椂闃绘柇鐤肩棝骞跺噺灏戠値鐥,浣嗛潪澶勬柟(OTC)姝㈢棝鑽疄闄呬笂骞舵病鏈夊府鍔╁姞鍥哄拰婊嬪吇鏋勬垚鍏宠妭鐨勫叧閿粨鏋勩
骞歌繍鐨勬槸,宸茬粡鍙戠幇璁稿鑶抽琛ュ厖鍓傛棦鑳芥敮鎸佸叧鑺傚仴搴,鍙堝叿鏈夊叾浠栫泭澶勩傝櫧鐒舵ユу垱浼や細瀵艰嚧閮ㄥ垎鍏宠妭鍔熻兘闅滅,浣嗗ぇ澶氭暟鍏宠妭閫鍖栭兘鏄紦鎱㈠彂鐢熺殑銆備繚鎸佸叧鑺傚仴搴峰拰鎬ц兘鐨勫叧閿槸姝ｇ‘鐨勮繍鍔ㄥ舰寮忋佷紭璐ㄧ殑鏃ュ父钀ュ吇鍜岄拡瀵规х殑琛ュ厖鍓傘傗
鏈浣冲叧鑺傝惀鍏荤礌:
1.鐢茬～姘ㄩ吀鐩(MSM)
鐢茬～姘ㄩ吀鐩(MSM)鏄竴绉嶅惈纭垎瀛,宸茬煡鍙互閫氳繃浠ヤ笅涓ょ鏂瑰紡鏀寔鍏宠妭鍋ュ悍:淇冭繘杞鐢熸垚鍜屽叿鏈夋姉鐐庝綔鐢ㄣ2 鈥
浜嬪疄涓,鐮旂┒浜哄憳鎸囧嚭:鈥...MSM琛嶇敓纭浜轰綋鍚告敹杩涘叆杞缁勭粐,杩欒〃鏄嶮SM鍙敤浜庨闃叉垨娌荤枟鐐庣棁鐩稿叧鐨勫叧鑺傜柧鐥呫傗 2 鈥
鏈杩戝湪12鍛ㄥ唴瀵规劅瑙夎啙鍏宠妭鐤肩棝鈥滆交寰濈殑鍋ュ悍鍙備笌鑰呯殑鐮旂┒鍙戠幇,姣忔棩琛ュ厖2000姣厠MSM鍙互鏀瑰杽鑶濆叧鑺傜姸鍐靛拰鍏ㄨ韩鍋ュ悍鐘跺喌,鐩告瘮瀹夋叞鍓傜粍鏈夋樉鐫宸紓銆2 鈥
杩欎竴鍙戠幇鍊煎緱鍏虫敞,鍥犱负杩欐槸棣栨閽堝鈥滃仴搴封濅釜浣撹繘琛岀殑涓村簥璇曢獙,鑰屼箣鍓嶇殑MSM鐮旂┒閮芥槸閽堝鎮ｆ湁楠ㄥ叧鑺傜値鐨勪釜浣撹繘琛岀殑銆3,4 鈥
2.钁¤悇绯栬兒
钁¤悇绯栬兒鏄敤浜庡叧鑺傚仴搴风殑涓ょ鏈甯歌鍜屼娇鐢ㄦ椂闂存渶闀跨殑鑶抽琛ュ厖鍓備箣涓(鍙︿竴绉嶆槸杞绱)銆傚畠鏄蒋楠ㄧ殑缁勬垚閮ㄥ垎,涔嬪墠鐨勭爺绌惰〃鏄庡畠鍙兘鏈夊姪浜庢敼鍠勫叧鑺傝垝閫傚害骞舵敮鎸佸仴搴风殑鍏宠妭銆5,6
闄や簡鏀寔鍏宠妭鐨勭壒鎬у,钁¤悇绯栬兒杩樹笌鍏朵粬鐩婂鐩稿叧,鐗瑰埆鏄湪蹇冭绠′唬璋㈠仴搴峰拰鍏ㄥ洜姝讳骸鐜囨柟闈7,8,9渚嬪,鍔ㄧ墿鐮旂┒琛ㄦ槑,钁¤悇绯栬兒鐨勭粰浜堝彲鑳芥ā褰蜂綆纰虫按鍖栧悎鐗╅ギ椋熺殑鏁堟灉,浠庤屽鍔犲鍛姐10鏈杩戠殑涓椤瑰叡鍖呮嫭杩48涓囧悕鍙備笌鑰呯殑涓栦唬鐮旂┒鍙戠幇,瀹氭湡琛ュ厖钁¤悇绯栬兒涓庡績鍔涜“绔闄╅檷浣庣浉鍏,涓庨仐浼犻闄╃姸鎬佹棤鍏炽11 鈥
鏂扮殑鐮旂┒涔熸寚鍑轰簡涓浜涜剳鍋ュ悍鐩婂銆備箣鍓嶇殑鐮旂┒琛ㄦ槑钁¤悇绯栬兒鍙互绌胯繃琛鑴戝睆闅(BBB),鍦ㄩ偅瑁″畠鍙兘鍏锋湁绁炵粡淇濇姢鍜屾姉鐐庝綔鐢ㄣ12,13 鈥
涓椤瑰湪鑻卞浗鐢熺墿鏍锋湰搴撳紑灞曠殑澶у瀷鐮旂┒,鍖呮嫭杩50涓囪嫳鍥戒汉鐨勬暟鎹,鍙戣〃鍦ㄩ珮搴﹀皧鏁殑BMC鍖诲鏉傚織涓,鐮旂┒浜嗗畾鏈熶娇鐢ㄨ憽钀勭硸鑳轰笌鍏ㄥ洜鎬уけ鏅虹棁銆侀樋灏旇尐娴烽粯姘忕棁鍜岃绠℃уけ鏅虹棁椋庨櫓鐨勫叧鑱斻14鍦ㄥぇ绾9骞寸殑闅忚鏈熷唴,鐮旂┒浜哄憳璁板綍浜2458渚嬪叏鍥犳уけ鏅虹棁,924渚嬮樋灏旇尐娴烽粯姘忕棁鍜491渚嬭绠℃уけ鏅虹棁銆傗
鍦ㄨ鐮旂┒缁撴潫鏃,鍥㈤槦鍙戠幇瀹氭湡琛ュ厖钁¤悇绯栬兒涓庡叏鍥犳уけ鏅虹棁椋庨櫓闄嶄綆15%銆侀樋灏旇尐娴烽粯姘忕棁椋庨櫓闄嶄綆17%鍜岃绠℃уけ鏅虹棁椋庨櫓闄嶄綆26%鐩稿叧銆14瀹氭湡鏈嶇敤钁¤悇绯栬兒鐨勪汉缇や腑,鐐庣棁鐢熺墿鏍囧織鐗〤鍙嶅簲铔嬬櫧(CRP)姘村钩鏄剧潃闄嶄綆銆15 鈥
3.杞绱
杞绱犵粡甯镐笌钁¤悇绯栬兒涓璧疯ˉ鍏,鑰屼袱鑰呯殑缁勫悎涓庡崟鐙娇鐢ㄧ浉姣,鍦ㄥ叧鑺傛敮鎸佹晥鏋滄柟闈㈢殑缁撴灉鏇翠负鏈夊埄銆16
杞绱犳槸涓绉嶈嚜鐒剁敓鎴愮殑鐗╄川,鍙府鍔╄韩浣撶淮鎸佸叧鑺備腑鐨勬祦鍔ㄦу拰寮规с傛垜浠箣鍓嶅己璋冪殑鐮旂┒琛ㄦ槑,琛ュ厖杞绱犲彲鑳戒細鏀瑰杽鍏宠妭鑸掗傚害鍜屾暣浣撶敓娲昏川閲忋16
涓庤憽钀勭硸鑳轰竴鏍,杞绱犱篃琚彂鐜板彲鎻愪緵鍏宠妭鍋ュ悍涔嬪鐨勭泭澶勩傚姩鑴夌‖鍖栨槸涓绉嶆參鎬х値鐥囨х柧鐥,绫讳技鍏宠妭鐐庢槸鐐庣棁鎬х柧鐥呫傜爺绌惰〃鏄,杞绱犲彲鑳戒細鎶戝埗NFkB淇″彿浼犲閫氳矾涓嬫父鐨勬煇浜涚値鐥囧洜瀛,鍖呮嫭IL-1尾銆両L-6銆乀NF-伪鍜孭GE2,浠ュ強COX-2鐨勮〃杈俱17,18
2021骞翠竴椤瑰ぇ瑙勬ā涓栦唬鐮旂┒,鍖呮嫭瓒呰繃370涓囦汉,鍙戠幇浣跨敤杞绱犱笌蹇冭剰鐥呭彂浣滈闄╅檷浣庣害40%鐩稿叧銆19杩欎簺鍙戠幇寰楀埌浜哅orrison绛変汉鍦20涓栫邯70骞翠唬棣栨鍙戠幇杞绱犳綔鍦ㄥ績琛绠＄泭澶勭殑鐮旂┒鐨勬敮鎸併20 鈥
棰濆鐨勫姩鐗╃爺绌惰繕鍙戠幇,杞绱犲彲鑳借兘澶熷噺灏戣绠″唴鏂戝潡鐨勫ぇ灏忓苟淇鍙楁崯鐨勮绠″銆21 鈥
涔抽灞炴鐗〣oswellia serrata鏄竴绉嶅叿鏈変赴瀵屼紶缁熺枟娉曞簲鐢ㄥ巻鍙茬殑妞嶇墿,灏ゅ叾瀵规參鎬х値鐥囨潯浠堕潪甯告湁鏁堛傜爺绌朵汉鍛樺凡缁忚瘑鍒簡涔抽涓瓨鍦ㄧ殑涓绉嶅叧閿敓鐗╂椿鎬ф垚鍒嗕箼閰板熀-11-閰-尾-榫熸澘棣欑儻閰(AKBA),鍙戠幇瀹冭兘鎶戝埗鐐庣棁鍜屾牳鍥犲瓙-魏B(NF-魏B)淇″彿閫氳矾銆22,23,24 AKBA涔熻璇佹槑鏄...5-鑴傛哀鍚堥叾(5-LOX)鐨勬渶寮烘姂鍒跺墏,杩欐槸涓绉嶈礋璐ｇ値鐥囩殑閰垛濄25 鈥
鏈鏂扮殑鐮旂┒琛ㄦ槑AKBA鍙兘瀵逛腑鏋㈢缁忕郴缁熴佸懆鍥寸缁忕郴缁熶互鍙婂厤鐤敮鎸佹湁鐩婂銆26,27,28 鈥
Wang绛変汉鏈杩戠殑涓瀵圭爺绌惰杞戒簡AKBA缁欎簣鍚庡娌荤枟鍧愰绁炵粡鎹熶激鏈夌缁忓啀鐢熺泭澶勩26,27 鈥 鍏蜂綋鏉ヨ,鐮旂┒浜哄憳娉ㄦ剰鍒:
鈥滃湪鍒嗗瓙姘村钩涓,AKBA鍙互閫氳繃鎶戝埗楂撹繃姘у寲鐗╅叾鐨勮〃杈惧拰鍑忓皯鐐庣棁鍙嶅簲鏉ュ鍔犵缁忚惀鍏诲洜瀛愮殑琛ㄨ揪,杩欏彲鑳戒績杩涘彈鎹熷潗楠ㄧ缁忕殑楂撻灅鍐嶇敓鍜岃酱绐佸啀鐢熴傗26
AKBA缁欒嵂褰卞搷鐨勭缁忚惀鍏诲洜瀛愬寘鎷剳婧愭х缁忚惀鍏诲洜瀛(BDNF)鍜岀缁忕敓闀垮洜瀛(NGF)- 杩欎袱绉嶇缁忚偨鍒嗗埆璋冭妭绁炵粡鍏冪殑鐢熼暱銆佸彂鑲插拰缁存寔銆26
鐮旂┒浜哄憳杩樻寚鍑,AKBA閮ㄥ垎閫氳繃鈥滃噺灏戠値鐥囧弽搴,淇冭繘楂撻灅鍜岃酱绐佸啀鐢熲濇潵澧炲姞杩欎簺绁炵粡钀ュ吇鍥犲瓙銆26
4.濮滈粍
浣滀负浜氭床鑿滆偞鐨勪富瑕侀厤鏂,濮滈粍鍦ㄤ腑鍖诲拰闃胯偛鍚犻檧鑽墿鐨勬姉鐐庢綔鍔涗篃鏈夋偁涔呯殑搴旂敤鍘嗗彶銆備簨瀹炰笂,2016骞寸殑涓椤硅崯钀冨垎鏋愬拰绯荤粺缁艰堪鍙戠幇,濮滈粍瀵规敼鍠勫叧鑺傜柤鐥涚棁鐘剁殑鏁堟灉涓庣儹闂ㄩ潪澶勬柟闈炵斁浣撴姉鐐庤嵂鐩稿綋銆29 鈥
濮滈粍绱犲強濮滈粍涓叾浠栫敓鐗╂椿鎬ф垚鍒嗗彲璋冭妭NF-魏B淇″彿閫氳矾銆佷績鐐庣棁缁嗚優鍥犲瓙濡傜櫧缁嗚優浠嬬礌鐨勪骇鐢熶互鍙婄７鑴傞叾A2銆丆OX-2鍜5-LOX鐨勬椿鎬с30,31
铏界劧濮滈粍/濮滈粍绱犲湪鍏宠妭鏀寔鍜岃垝缂撴ф柟闈㈢殑鍔熸晥宸插湪鐮旂┒鍜屼紶缁熷簲鐢ㄤ腑寰楀埌鑹ソ寤虹珛,浣嗘柊鐨勭爺绌朵粛鍦ㄦ寔缁繘琛屽拰鍙戣〃銆傛渶杩,涓椤瑰惈鏈夊榛勭殑婧峰悎鐗┾滃噺杞讳簡KOA(鑶濆叧鑺傞鐐)鎮ｈ呯殑鍏宠妭鐤肩棝,鏀瑰杽浜嗚倢鑲夐楠煎姛鑳藉拰鍏宠妭娲诲姩鑳藉姏鈥濄32 鍙楄瘯鑰呭湪30澶╁唴鏈嶇敤瀹夋叞鍓傘250mg濮滈粍/閲戞ū瀛愭彁鍙栫墿鎴1000mg濮滈粍鍜屼钩棣欐彁鍙栫墿鐨勬悍鍚堢墿銆傛湇鐢ㄥ榛/閲戞ū瀛愭悍鍚堢墿鐨勪汉鍛樻敼鍠勪簡韬綋鏈鸿兘,鍑忚交浜嗗叧鑺傜柤鐥涘拰鍍电‖鐨勭棁鐘躲32 鈥
5.鑳跺師铔嬬櫧(浼撮殢缁寸敓绱燙!)
鑳跺師铔嬬櫧鏄綋鍐呮渶涓板瘜鐨勮泲鐧借川,涓轰綘鐨勮韩浣撴彁渚涚粨鏋勫拰鐢熺墿鈥滅矘鍚堝墏鈥,浣胯韩浣撳悇閮ㄥ垎绱у瘑缁撳悎銆傝兌鍘熻泲鐧藉瓨鍦ㄤ簬澶村彂銆佺毊鑲ゅ拰鎸囩敳,涔熷瓨鍦ㄤ簬楠ㄩ銆侀煣甯︺佸叧鑺傘佽蒋楠ㄣ佽倢鑲夊拰琛绠′腑銆
灏界浣撳唴瀛樺湪杩30绉嶄笉鍚岀被鍨嬬殑鑳跺師铔嬬櫧,浣嗘渶涓板瘜鐨勭被鍨嬫槸:
鈥鍨
鈥I鍨
鈥II鍨
韬綋澶╃劧浼氫骇鐢熻兌鍘熻泲鐧(浣嗕笌澶у鏁颁簨鐗╀竴鏍),闅忕潃骞撮緞澧為暱,韬綋鍚堟垚鑳跺師铔嬬櫧鐨勮兘鍔涗細涓嬮檷銆傝ˉ鍏呰兌鍘熻泲鐧芥彁渚涗簡涓涓粡娴庡彲琛岀殑閫夋嫨,閫傚悎閭ｄ簺瀵绘眰澧炲姞鑳跺師铔嬬櫧鑲芥憚鍏ラ噺鐨勪汉缇ゃ
浣跨敤鐗涙簮鑳跺師铔嬬櫧鑲(瀵屽惈I鍨嬪拰III鍨)涓嶶C-II(2鍨嬭兌鍘熻泲鐧)鐨勭粍鍚堝彲鍒烘縺鑳跺師铔嬬櫧鐨勪骇鐢,骞舵彁渚涙敮鎸佽兌鍘熻泲鐧藉悎鎴愭墍闇鐨勫叧閿皑鍩洪吀(鐢樻皑閰搞佽劘姘ㄩ吀鍜岀緹鑴皑閰)銆33,34
闄や簡涔嬪墠鐨勭爺绌惰瘉鏄庤兌鍘熻泲鐧借ˉ鍏呭鍏宠妭鐨勬敮鎸佺泭澶,2018骞寸殑绯荤粺缁艰堪鎬荤粨閬,灏嗙淮鐢熺礌C(涓绉嶆祦琛岀殑鍏嶇柅鏀寔琛ュ厖鍓傚拰鎶楁哀鍖栧墏)涓庤兌鍘熻泲鐧界粍鍚堚滃彲鑳戒細淇冭繘楠ㄦ姌鍚庨楠兼剤鍚,澧炲姞I鍨嬭兌鍘熻泲鐧界殑鍚堟垚,骞跺噺灏戞哀鍖栧簲婵鍙傛暟鈥濄35 鈥
鍙傝冿細
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